Chemistry and Biochemistry

Chemistry 412: Chemical Kinetics

Last update: for Spring 2025

Instructor: Andrew Cooksy CSL-310

Chemical Kinetics
Syllabus

Lecture Meetings: TuTh 5:30-6:45pm, AH-3150
Office Hours: Mon 10-11am CSL-310. These office hours are shared with another class.
Textbook: Steinfeld, Francisco, Hase Chemical Kinetics and Dynamics, 2nd ed., to be on sale in campus bookstore, and used copies ok.

Errors in Steinfeld, Francisco, and Hase, 2nd edition

Prerequisites

Students should have completed a year of undergraduate physical chemistry (SDSU's Chem 410A and 410B or equivalent). We will use some calculus at about that level. If we need other tools from math (linear algebra, transforms), they will be introduced as needed.

This Course in Your Degree

This course fulfills 3 units of the Chemistry and Biochemistry B.S. and B.A. degree upper division elective requirements.

General Idea

This course is intended to benefit chemistry students in all areas, as well as students in other departments with interests reaction chemistry. I plan to talk about chemical kinetics of enzymes, hydrocarbon combustion, interstellar gases, and organometallic catalysts. Many of these will be as specific examples of the broadly applicable general principles that we will discuss.

You're welcome to see me or email me if you want to ask about the course content or suitable preparation for the course. The emphasis should be on the principles of kinetics common to all applications of chemistry, so students are encouraged to bring issues from their own research (or other interests) to my attention for discussion (the sooner the better).

Student learning objectives:

At the conclusion of the course, the student should be able to:

Articulate the basic principles of Chemical Kinetics;
describe the fundamental properties that determine chemical reaction rates;
carry out basic calculations on reaction rates using the rate law and numerical rate parameters;
estimate elementary reaction rate constants based on transition state theory or collision theory models;
evaluate the literature regarding kinetic measurements of complex reaction systems;
calculate complex reaction rate constants and concentration dependencies using accurate computational techniques and the reasonable application of useful approximations such as the steady state, fast equilibrium, or pseudo-lower order approximations.

These goals may be adapted to suit the needs and wishes of the students.

Course material

Chemical reaction dynamics and kinetics; primarily an examination of chemical kinetics from the microscopic perspective. I want to cover kinetics in broad enough manner to make applicable to everyone doing reaction chemistry.

This year, I hope to model the course after a Chemical Engineering course in kinetics that I sat in on during my sabbatical last year at MIT. That course used this same textbook (which is n fact the one we normally use at SDSU) but because it was a chemical engineering course, there was more emphasis on practical questions, especially

what are the experimental challenges in getting good kinetics data?
what are the best options for estimating reaction rates when experimental data is not available?

Topics:

Theory: Potential energy surfaces and reaction diagrams; Molecular collisions and simple collision theory; Transition state theory and the Really Scary Stuff; Classical kinetics and obtaining the integrated rate laws
Experiment: Reaction system design; Probe methods: spectroscopy, mass spectrometry, classical analytical techniques; What to do with the data
Applications: protein folding; interstellar chemistry; organic synthesis; surface chemistry; Your Application Here

Organization

I want to deviate occasionally from the textbook, which is somewhat arbitrary in the ordering of topics. We will just lay the necessary groundwork for the microscopic picture by recapitulating the relevant results from quantum mechanics of individual molecules and a little statistical mechanics. We will not do any quantum in this course, however. The main point is that the macroscopic kinetics is more understandable when you appreciate what's happening at the molecular scale. So we start with a little about molecular collisions and potential surfaces for reactions (which are in the middle of the book), but then we pick up at chapter 1 and go through essentially the text's presentation of the material. I will probably add a few things and skip things as we go along. I hope to do lots of examples, but you'll need to keep me to my word on that.

Prerequisite Math

You should be very comfortable with algebra and the simplest derivatives and integrals (especially e^-xdx). We might cover some matrix algebra and Laplace transforms, but you need not have seen these before, and we will focus on how to use computational solutions rather than solving on paper.

Grading criteria

Grading Scheme

in-class assignments: 15%
homework: 25%
exam 1: 30%
exam 2: 30%

There is no final exam.

grade	range
A	85-100%
B	70-85%
C	55-70%

Exam Dates for Spring 2025

exam 1: Tue Mar 15
exam 2: Thu May 8

There is no final exam.

Exams

All exams are open-book and given in-class. No communication with other naturally or artifically intelligent entities regarding any aspect of the exam is permitted during the exam period. For these purposes, the instructor is not to be considered an intelligent entity, so you may discuss the exam with me by email, during office hours, or by appointment. (Also for these purposes, assistance via the Internet is considered communication with intelligent beings, in case you were wondering.)

Errors in the text

In my experience, Steinfeld, Francisco, and Hase is widely considered to be the best text available on this topic. I hope you find it readable and informative. It does, however, have a few proofreading errors which you should correct in your copy:

p. 7, Eq. 1-27. the denominator on the left side should be [A], not dt.
p. 9, after Eq. 1-45. Solve the right side of 1-45 and equate it to the right side (not left) of Eq. 1-44.
p. 23, Eq. 2-7. The first line should end -[A₁], not +[A₁]. The next two lines are then correct.
p. 29, Eq. 2-43. The second "=" sign should be removed, so that [A₁]₀ multiplies the whole expression.
p. 32, Eq. 2-70. The second equation is the solution for [A₂], not [A₁].
p. 33, Eq. 2-76. Remove the "-" from the right side.
p. 40, after Eq. 2-133. The concentration of [A₁], not [A₂], remains nearly constant.
p. 54, Eq. 2-209. The bottom term in the last vector should be k₁-k₁e^{-(k₁+k₂)t}, not k₁+k₁e^{-(k₁+k₂)t}.
p. 118, Eq. 3-77. The denominator on the left should be K₂, not K₁.
p. 151, bottom of page. The second "=" should be "-".
p. 467, Table 14-1. Columns 3 and 4 are missing the powers of ten (available from the original paper, Combust. Sci. Tech. 15, 99 (1976)) and the products for reaction 12 should be CO + H₂O, not CO + OH.

Land Acknowledgment

For millennia, the Kumeyaay people have been a part of this land. This land has nourished, healed, protected, and embraced them for many generations in a relationship of balance and harmony. As members of the San Diego State University community, we acknowledge this legacy. We promote this balance and harmony. We find inspiration from this land, the land of the Kumeyaay.

Essential Student Information

For essential information about student academic success, please see the SDSU Student Academic Success Handbook.

SDSU provides disability-related accommodations via Student Disability Services (sds@sdsu.edu |https://sds.sdsu.edu/). Please allow 10-14 business days for this process.

Class rosters are provided to the instructor with the student's legal name. Please let me know if you would prefer an alternate name and/or gender pronoun.

Students should not use generative AI applications in this course except as approved by the instructor. Any use of generative AI outside of instructor-approved guidelines constitutes misuse. Misuse of generative AI is a violation of the course policy on academic honesty and will be reported to the Center for Student Rights and Responsibilities.